[J.F] Kennedy's own accent was inconsistent. So people are inconsistent. And it always kind of irks me when people talk about inconsistent accents, because people are imperfect by nature. So in the end, what you do is, you do an inhabitation and not an imitation.

So I came to the realization: Nothing in life is unfair. It's just life.

You can meet people who are really beautiful. Then, when you see them angry for the first time, all of a sudden they're not beautiful anymore. They didn't just step into the other room and have plastic surgery; they're still the same physically. It's just that something inside of them has changed. They're no longer attractive.

In the business of acting, those are the actors that make the trains run on time, you know? There's nothing without them.

I literally knew nothing when I did that show ["Tony Flanagan"]. It was the first time I signed an autograph, it was the first time I got fan letters, it was the first time people screamed when I came out.

I'm thinking of how unexpected and yet oddly preordained life can be. Events are upon you in an instant, unforseen and without warning, and often times marked with disappointment and tragedy, but equally often leading to a better understanding of the bittersweet truth of life.

One of my favorite books [The Stand] of all time. I grew up reading it.

I think of myself as a human being first and foremost, and secondly as a person whose profession is acting. If people want to make that into something more or less, that's up to them.

I remember Tucker Toomey was named so because "T's are funny!" And if Garry Marshall says it's funny, by god, it must be so.

All the shows we did pre-airdate, and I'd come out - "Rob Lowe!" - and it was [Offers bored applause.] After the show aired? I came out - "Rob Lowe!" - and the place was, like, bedlam. And then the next week, they wouldn't let anyone under the age of 20 into the audience. And I'm going, "So that's how it works! Okay!"

We knew we were doing something that would make an impact, because of Francis [Ford Coppola], but I don't think we were surprised by how well the movie [The Outsiders] did, but I think we would all say we were surprised at how well we all did coming out of it.

I’ve never agreed with the conventional wisdom that ‘actors are great liars.’ If more people understood the acting process, the goals of good actors, the conventional wisdom would be ‘actors are terrible liars,’ because only bad actors lie on the job. The good ones hate fakery and avoid manufactured emotion at all costs. Any script is enough of a lie anyway. (What experience does any actor have with flying a spacecraft? Killing someone?) What’s called for, what actors are hired for, is to bring reality to the arbitrary.

I really make a point of never worrying, or trying not to worry, about the way I'm perceived. You'll go crazy otherwise.

Allison Janney is the best actor on the series.Allison is one of the few actors I ever worked with who is incapable of hitting a false note.

Adventure is important in life. Making memories matters. It doesn’t have to be a secret sea plane and an historic sports moment. But to have a great life, you need great memories. Grab any intriguing offer. Say yes to a challenge, and to the unknown. Be creative in adding drama and scope to your own life. Work at it, like a job. Money from effort comes and goes. But effort from imagination and following adventure creates stories that you keep forever. And anyone can do it.

The umbrella that I live under is that you must be truthful with everyone except when to do so would injure them or others.

Mostly people are interested in how somebody becomes an actor. And then, if they've had a couple of drinks, they want to know what Demi Moore's like or whatever. I mean, I don't mind people asking that at all, but when you've answered it five times...

Your interests change. I used to feel that if I spent evenings reading, or watching a film, or just doing nothing up here at the house, I would probably be missing something that was a lot more fun. I don't have that sense anymore.